The Mar Thoma Syrian Theological Seminary is focusing on developing the infrastructure and facilities of learning. The main campus of the Mar Thoma Syrian Theological Seminary is situated on the Railway Station Road Kottayam at the Zion Hills. It is situated between the Mar Thoma Seminary Higher Secondary School and the St. Joseph's Girls Higher Secondary School, Kottayam. The campus has the administrative block, Class Rooms, Main Hostel, Annexe, Ladies Hostel, M. Th. Quarters, D. Th. Quarters, Faculty Quarters and Staff quarters. It also houses the famous main building where the Kottayam District Court was convened during the Daniel Case (The case given against Yuhanon Mar Thoma Metropolitan by K. N. Daniel) and the Abraham Malpan Memorial Chapel. The Library and the Seminary Achieves is also situated in this campus.
Seminary also has an extension campus at Karukachal that consists of 15 acres of land. There are two buildings at Karukachal, a hostel cum Dining Hall and Staff Quarters for the Faculty. We have also constructed a new Administrative Block at Kottayam Campus.